Jermain Defoe was left out of the starting XI at Southampton after Fabio Borini was preferred to Sunderland's top scorer.
Borini - who netted a stunning last-minute equaliser against Crystal Palace in midweek - was recalled at the expense of Defoe in a switch which saw Dame N'Doye moving into a central role.
That was one of two changes from Sunderland boss Sam Allardyce, with Younes Kaboul taking the place of captain John O'Shea, who wasn't risked despite recovering from a calf injury.
Southampton: Forster, Clasie, Fonte, S Davies, Mane, Tadic, Romeu, Martina, Van Dijk, Pelle, Bertrand. Subs: Stekelenburg, Cedric, Yoshida, Ward-Prowse, Reed, Juanmi, Olomola
Sunderland: Mannone, Yedlin, Kaboul, Kone, van Aanholt, Kirchhoff, M'Vila, Rodwell, Khazri, Borini, N'Doye. Subs: Pickford, Jones, Larsson, O’Shea, Defoe, Toivonen, Mandron