Emergency services were called to a collision on the A1 (M) northbound near Carrville Interchange, Durham around 2.30 pm on Friday afternoon May 28).
One man was taken to University Hospital of North Durham.
Lane 2 had to close and average speed on approach to the incident was less than 10 mph, Highways England said in a tweet.
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It later tweeted that all lanes had reopened, with delays on approach of about 50 minutes.
Durham Police said: “Emergency services were called at 2.40pm today to reports of a collision on the A1(M)northbound just after the Carrville Interchange.
“Nobody is believed to have been injured in the incident.”
A spokesperson for the North East Ambulance Service said: “We were called at 2.23 pm to a reports of a road traffic collision involving four vehicles.
"We sent one ambulance and one of our hazardous area response teams.
"We’ve taken one male patient to University Hospital of North Durham.”