RONNIE Moore has handed starts to Scott Fenwick and Marlon Harewood with defender David Mirfin missing out with a toe injury.
The on-loan Scunthorpe United defender is set to go for a scan next week.
The injury means Moore has also changed formation, with Pools lining up in a 4-4-2 formation, with Fenwick set to start on the left-wing.
Harewood has been recalled to the starting line-up after scoring the equaliser in the 1-1 draw against Accrington Stanley on Tuesday night.
Pools start the day third bottom, a point above the drop zone with just three games left to play.
John Still’s Luton are 8th and can still make the play-offs.
Luton (4-4-2): Justham, Harriman, Wilkinson, McNulty (C), Griffiths, Whalley, McGeehan, Smith, Howells, Cullen, Lee.
Subs: King, Lacey, Wall, Miller, Guttridge, Hall, Kinsella.
Pools (4-4-2): Flinders (C), Duckworth, Harrison, D Jones, Austin, Franks, Featherstone, Tshibola, Fenwick, Hugill, Harewood.
Subs: Maxted, Richards, Parnaby, Bates, Walker, Nelson-Addy, J Jones.
Referee: Gary Sutton (Lincolnshire)