Dave Challinor’s side will be looking to end a run of three games without a win when they visit the Kassam Stadium though they may have their work cut out against the League One high-flyers.
The U’s recently held their own against Manchester City in the EFL Cup quarter final and are challenging for promotion from the third tier going into the second half of the season.
The winners will earn a place in the last 32 of the prestigious competition as well as £135,000 from the prize pot. Scroll down and click through the pages to see our predicted Pools line-up for the match...
1. GK - Mitchell Beeney
Didn't do an awful lot wrong on his debut on New Year's Day. Could be given a chance once again in favour of Ben Killip. Photo: Mark Fletcher
2. CB - Peter Kioso
Pools most consistent defender, should be one of the first names on the team sheet. They could have trouble keeping hold of the 20-year-old this January with a number of EFL clubs keeping tabs on his progress. Photo: Mark Fletcher
3. CB - Michael Raynes
Put in some excellent displays in the FA Cup so far and will be hoping to continue that form on Saturday and hopefully back into the National League against Eastleigh on Tuesday night. Photo: Mark Fletcher
4. CB - Fraser Kerr
Gary Liddle being cup-tied could give the Scottish defender another chance to impress after a frustrating afternoon against Barrow last time out. Photo: Mark Fletcher