The Boro head coach has a couple of players unavailable through injury while there is also competition for places in some areas of the pitch. Our Boro writer Joe Nicholson has picked the starting XI he would choose to face the Royals. Scroll down and flick through our gallery to see if you agree.
1. GK: Darren Randolph
Will be hoping to keep his second clean sheet of the season against the Royals. Photo: Lewis Storey
2. RB: Anfernee Dijksteel
After a slightly sticky start the young full-back, 22, has improved in recent weeks. Jonny Howson's injury should give him a run in the side. Photo: Getty Images
3. CB: Dael Fry
Captained the side at Bristol City on his return from injury. The 22-year-old centre-back will be a key player for Woodgate this season. Photo: Getty Images
4. CB: Ryan Shotton
Woodgate has a decision to make at centre-back with Daniel Ayala available once again. Shotton was arguably Boro's best defender at Bristol City, though, and deserves to keep his place. Photo: Frank Reid