Three vehicles were involved in the collision on the A689 Stockton Road westbound at around 7.40am on Tuesday, October 5.
All three emergency services attended.
Cleveland Police said three vehicles were involved and that one male driver was taken to hospital by a family member.
Another man was taken to hospital by ambulance.
Their injuries are said not to be life threatening.
The collision caused severe traffic delays with long tailbacks in the area.
Police said one lane of the A689 was reopened fairly quickly and the incident was declared closed by 11am.
A spokesperson for the North East Ambulance Service said: "We received a call at 7.47am this morning to reports of a four-vehicle road traffic collision on the A689 near Billingham.
"We dispatched one ambulance crew, and took one patient to North Tees Hospital for further treatment."