The O’s scored four times on their way to three points as supporters were left to make the long journey home empty handed.
Pools did give their fans something to cheer about through Wes McDonald’s fine equaliser and Josh Umerah’s penalty in the second half.
But, for the 249 travelling supporters, it was another defeat on the road.
And here is our latest Pools fan gallery.
1. Hartlepool United
Hartlepool United hosted Leyton Orient at the Suit Direct Stadium. (Photo: Mark Fletcher | MI News) Photo: Mark Fletcher
2. Hartlepool v Leyton Orient
Hartlepool United went up against League Two leaders Leyton Orient. (Photo: Mark Fletcher | MI News) Photo: Mark Fletcher
3. Arriving
Pools supporters arrive at the Suit Direct Stadium. (Photo: Mark Fletcher | MI News) Photo: Mark Fletcher
4. Finger Crossed
Hartlepool United supporters were hoping for a positive result against Leyton Orient. (Photo: Mark Fletcher | MI News) Photo: Mark Fletcher