A sluggish start saw John Askey’s side fall behind inside five minutes when Jack Bridge was on hand to convert from close range following Harry Cardwell's header back across goal.
Pools began to settle, however, and eased themselves into the game before Tom Crawford levelled the scores with a fine finish from the edge of the area.
Askey’s side had one or two chances to take the lead before the break but it would be the Shrimpers who hit the front once more when Gus Scott-Morriss headed in from Callum Powell’s cross early in the second half.
Askey was forced into a change in the midst of falling behind for a second time when Emmanuel Dieseruvwe was taken off but his replacement Joe Grey made an instant impact when netting Pools’ second equaliser of the day.
And Hartlepool went on to claim all three points when Charlie Seaman scored his second goal in as many games to claim a third straight win.
And this is how Pools were rated in their Roots Hall success:
9. Anthony Mancini - 8
Another top performance from the Frenchman. Grew into things well in the first half and made some excellent runs from midfield. Linked well with the front two and went close twice in the first half. Most of Hartlepool’s positive work in the second half came through him. Went off to a standing ovation from the home fans. Excellent. Picture by FRANK REID Photo: FRANK REID 2022
10. Chris Wreh - 7
Struggled at times in the first half before establishing himself as a bit of a threat. Close when curling wide. Clever step-over to tee up Dieseruvwe. His link up play was very good after the break. Nicely weighted pass for Grey to assist the second. Picture by FRANK REID Photo: FRANK REID NATIONALWORLD 2022
11. Emmanuel Dieseruvwe - 6
Held the ball up quite well at times in the first half and allowed Pools to finally get out. Close when firing wide early in the second half. Forced off with a blow to the head just before Southend scored their second. Picture by FRANK REID Photo: FRANK REID 2022
12. Joe Grey - 8
A superb cameo. Instant impact from the bench when hammering home and was a constant threat on the counter-attack. Found space time and again on the right. Good set-up for Cooke. Key contribution to turn the game in Hartlepool's favour. Picture by FRANK REID Photo: Frank Reid