John Askey's side earned back-to-back wins for just the second time this season by sealing a league double over the Mariners inspired by Dan Kemp’s hat-trick.
Kemp netted once in the first half before adding his second and third of the game in an eight minute blitz from Pools just after the hour to take the game away from the home side.
Kemp first converted from David Ferguson’s cross in the first half when controlling well before finding the bottom corner.
The MK Dons loanee then kept his composure from 12-yards to restore the lead for Pools after Michee Efete had levelled the scores for the Mariners 10 minutes after the restart.
And Kemp grabbed his hat-trick when finding the bottom corner from Wes McDonald's ball before Josh Umerah added a fourth.
And here is how Pools were rated on a memorable afternoon at Blundell Park:
9. Dan Kemp - 10
Hat-trick hero and put a two-game slump, if you dare call it that, to bed with a superb display and a remarkable show of finishing. Touch and finish for the first was exquisite, the composure for the penalty excellent and the third with his right foot sublime. Nine goals in 12 appearances. What a player Hartlepool have here. (Photo: Mark Fletcher | MI News) Photo: Mark Fletcher
10. Connor Jennings - 8
Excellent in the first half. Covered every blade of grass. Great link up with several players but particularly Ferguson including for the opening goal. Was tasked with more defensive duties in the second half. Exceptional attitude and work rate. (Photo: Mark Fletcher | MI News) Photo: Mark Fletcher
11. Josh Umerah - 8
Felt like it might have been one of those days again for Umerah where he battled but never got anything to show from it. Brilliant strength to brush off the defender on halfway and deserved a second go from the rebound for the goal. 15 for the season. (Photo: Mark Fletcher | MI News) Photo: Mark Fletcher
12. Taylor Foran - 7
Brought on for Sterry at half-time and was under the cosh initially with Grimsby starting the second half well but stood up to it. Dragged out slightly for the goal but made some key headers and covered well. (Photo: Michael Driver | MI News) Photo: Michael Driver