John Askey saw his side claim back-to-back wins on home soil against Gateshead and Maidenhead United and will be looking to carry that into the trip to Roots Hall.
Pools lost their first away game of the season at Barnet and face a Shrimpers side who scored an emphatic win over Oldham Athletic last time out on home soil.
But will Askey stick with the side who enjoyed a 3-1 success in midweek? Here we predict our starting XI for the weekend trip to Essex:
9. Anthony Mancini
Mancini starred in the midweek win over Maidenhead and scored his first goal for his new club in the process. Picture by FRANK REID Photo: Frank Reid
10. Chris Wreh
Wreh replaced the suspended Josh Umerah in midweek and is likely to continue against his old club at Roots Hall. Picture by FRANK REID Photo: FRANK REID
11. Emmanuel Dieseruvwe
Dieseruvwe will lead the Hartlepool attack at Southend. Picture by FRANK REID Photo: Frank Reid