Pools took a surprise early lead against the League One outfit as Mark Kitching pounced on a defensive error to net his second goal of the season.
The visitors held on to their lead until the 52nd minute when Rob Hall curled in an equaliser. Shandon Baptiste then put the hosts ahead before Tarique Fosu and a Matty Taylor penalty added some gloss to the scoreline late on.
Scroll down and click through the pages to see our Pools player ratings from the match...
13. Tyler Hamilton (on for Richardson 70) - 6
Got involved best he could in the closing stages as the visitors failed to find a way back into the game. | Other 3rd Party Photo: Mark Fletcher
14. Luke Molyneux (on for Raynes 83) - n/a
Had a half chance in the box but the game was quickly put to bed by Oxford shortly after his introduction. | Other 3rd Party Photo: Mark Fletcher