Neil Warnock's men secured all three points with a commanding 3-0 win over Stoke City at the weekend – a result that kept them within eight points of the play-off places.
By contrast, Preston suffered a shock 1-0 defeat at the hands of bottom club Wycombe, and are now languishing 15th in the table.
Speaking to Sky Sports ahead of Tuesday night’s clash with Boro, Prutton predicted that North End could be in for more woe too.
The pundit predicts a 2-0 win for the Teessiders.
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Preston ran out 3-0 winners when the two sides last met in December.
Brad Potts, Scott Sinclair, and Emil Riis Jakobsen were on the scoresheet at Deepdale that day.
Boro haven’t beaten North End since New Year's Day 2020, with Rudy Gestede and Ashley Fletcher both scoring in a 2-0 victory.