Boro have failed to beat the Bees in their last five encounters, the most recent of which saw them knocked out of the FA Cup with a 2-1 defeat in west London.
As things stand, Neil Warnock’s side stand an excellent chance of making the play-offs, and picking up a big win against the Bees would be an excellent morale-booster as they look to continue their push towards a top-six finish.
Ahead of the weekend's clash, Warnock discussed star men Paddy McNair and Marcus Tavernier, and claimed: "For me, Paddy could play at any level now, he could play in the top half of the Premier League."
“I think he knows now to forget about midfield because he’s just an average player in midfield but at the back he’s unbelievable.
“Tav has got a lot to learn but he is learning all the time, he frustrates a manager and can pick an argument with his shadow at times but other than that he’s learning all the time and he will improve."
Here's our round-up of all the latest news and transfer chat involving Middlesbrough and a number of their divisional rivals, as we gear up for another action-packed weekend of second-tier football.
5. Cafu signs permanent Forest deal
Nottingham Forest have confirmed the permanent signing of defensive midfielder Cafu from Olympiacos. The ex-Portugal youth international was snapped up after impressing on a loan spell with the club. (Club website) Photo: James Chance
6. Luton target subject of rejected bid
Gillingham boss Steve Evans has revealed the club received a "real good offer" for star man Kyle Dempsey, which was turned down. He was heavily linked with Luton Town throughout the January transfer window. (The 72) Photo: James Chance
7. Smith close to Swans return
Swansea City look set to welcome back key midfielder Korey Smith to the side for their clash against fellow promotion contenders Norwich City on Friday. He's been out since the middle of last month with a quad injury. (Club website) Photo: Harry Trump
8. Hammers miss out on Riley
Reports have revealed that West Ham United failed in their attempts to sign starlet Regan Riley from Bolton Wanderers, before the teenager joined Norwich City. The Canaries sealed the deal with a fee in the region of £250k. (Football Insider) Photo: Clive Rose