The Boro boss will still be without several first-team players, including Dael Fry, Anfernee Dijksteel, Sam Morsy and Marcus Tavernier, due to injury.
It means the Teessiders’ bench will once again be made up of mostly under-23s players, including teenage striker Josh Coburn, who recently scored his first senior goal against Sheffield Wednesday.
Warnock has been deploying a back three in recent weeks due to his lack of options, with Paddy McNair, Grant Hall and Marc Bola starting in defence.
Boro will start the day 10th in the Championship and have little to play for in terms of their divisional status for next season.
Wycombe, meanwhile, sit bottom of the division and, while they haven’t mathematically been relegated, their inferior goal difference has realistically ended their survival hopes.
Here’s how Boro could start.
9. CAM: Hayden Coulson
Played in a central role at Luton yet it's still unclear where the 22-year-old will fit into Boro's side long term. Photo: George Wood
10. ST: Yannick Bolasie
Boro fans will hope this isn't Bolasie's last game for the club as his loan deal is set to expire. Warnock hasn't ruled out re-signing the attacker. Photo: Stu Forster
11. ST: Duncan Watmore
Boro's top scorer this season despite only arriving in November. Scored for the ninth time this campaign at Luton. Photo: Stu Forster