Neil Warnock’s side are still just two points above the relegation zone and will be hoping to bounce back following Saturday's 3-1 defeat by Bristol City. Our Boro writer Joe Nicholson has picked the side he would choose to face the Royals – scroll down and flick through our picture gallery to see if you agree:
5. CB: George Friend
Has started every game at centre-back under Warnock and has looked more comfortable in a back three. Photo: Tony Marshall
6. LWB: Hayden Coulson
Warnock has preferred playing Marvin Johnson at wing-back, yet Coulson seems a more natural fit if the youngster can rediscover his form from earlier in the season. Photo: Jan Kruger
7. CDM: Jonny Howson
Has been deployed in front of Boro's defence in recent weeks and is better suited to a midfield role. Photo: Getty Images
8. CM: George Saville
Has started every game under Warnock, showing improvements in a box-to-box midfield role. Photo: Alex Davidson