The Royals have won all four of their league games so far this season and have already beaten the likes of Watford, Cardiff and Derby.
Yet Boro will also be feeling confident after a 2-1 win over Barnsley before the international break.
Scroll down and flick through our picture gallery to see our predicted Boro line-up:
1. GK: Marcus Bettinelli
Warnock has made it clear the 28-year-old will be his No.1 goalkeeper this season after joining from Fulham on loan. Photo: Stu Forster
2. RWB: Marcus Tavernier
Performed well in the right wing-back role against Barnsley last time out and deserves to keep his place in that position. Photo: Getty Images
3. CB: Anfernee Dijksteel
Looks comfortable on the right of a back three and has been one of Boro's best players so far this season. Photo: Richard Heathcote
4. CB: Dael Fry
Produced a man of the match performance in the heart of Boro's defence against Barnsley last time out. Photo: Owen Humphreys