Elliot Durrell’s second half strike made it three straight defeats without a goal for Pools.
The hosts should have taken the lead in the first half through Luke Molyneux and Tom Crawford but they were ultimately left to rue their missed chances.
Dave Challinor's side pushed for an equaliser late on but Wrexham held out to take three points.
Scroll down and click through the pages to see the confirmed Pools line-up for tonights’s match...
1. Henrich Ravas - 6
Could do little about the goal but was rarely tested otherwise. Photo: HUFC/Alex Chandy
2. Lewis Cass - 6
Some good link up play down the right in the first half but faded as the game went on. Photo: MI News
3. Tyler Magloire - 6
Looked composed on the ball with some solid distribution but caught out of position on occasion. Photo: HUFC/Alex Chandy
4. Ryan Johnson - 7
Was an important presence at the back with some strong defensive headers. Photo: Mark Fletcher