After a goalless draw with the Red Devils, which went to extra-time, Boro claimed a memorable 3-1 win in the subsequent penalty shootout in front of 10,000 jubilant away supporters. Scroll down and flick through our picture gallery to see the side which played:
5. LB: George Friend
After seven years on Teesside, the 32-year-old has been made captain at the Riverside. He's made just one league appearance this season due to injury though. Photo: Matthew Peters
6. CM: Jack Stephens
Predominantly a centre-back, the 25-year-old is back at Southampton after his loan spell at the Riverside. Stephens made 24 Premier League appearances last season but has featured just twice in the league for the Saints this term. Photo: Matthew Peters
7. CM: Grant Leadbitter
Rejoined his boyhood club Sunderland in January and missed out on League One promotion with the Black Cats. Has been in and out of the side in recent weeks. Photo: Shaun Botterill
8. RW: Emilio Nsue
Joined Greek side Apollon Limassol earlier this year after leaving Cyprian club APOEL Nicosia. Also had a spell at Birmingham after leaving Boro. Photo: Shaun Botterill