Dave Challinor’s side beat Aldershot Town 2-1 on the opening weekend of the 2020-21 National League season.
Now they make the trip to Derbyshire to face a Chesterfield side they beat 5-1 last time the sides met.
Pools will have Luke Molyneux misses out following his self-isolation period after testing positive for coronavirus. Striker David Parkhouse is also unavailable as he joins up with the Northern Ireland under-21s squad this week.
Scroll down and click through the pages to see our predicted Pools line-up for the game...
1. GK: Ben Killip
Made a solid start to the season against Aldershot with a handful of smart saves. Should keep his place between the sticks. Photo: Frank Reid
2. LB: David Ferguson
Looks to be a solid summer aquisition by Challinor. His deliveries from the left flank will cause teams problems. Photo: Christopher Booth
3. CB: Gary Liddle
Marked his 300th appearance for Pools with a win on Saturday. Photo: Christopher Booth
4. CB: Timi Odusina
The young centre-back is quickly establishing himself as a key member of the Pools squad. Photo: Christopher Booth