Pools took a surprise early lead against the League One outfit as Mark Kitching pounced on a defensive error to net his second goal of the season.
The visitors held on to their lead until the 52nd minute when Rob Hall curled in an equaliser. Shandon Baptiste then put the hosts ahead before Tarique Fosu and a Matty Taylor penalty added some gloss to the scoreline late on.
Scroll down and click through the pages to see our Pools player ratings from the match...
5. Mark Kitching - 7
Reacted well to pounce on Oxford’s error at the back and slot home his second goal in his last four starts. Clumsy at times but should have been awarded a penalty after another bursting run into the box on the stroke of half time. | Other 3rd Party Photo: Mark Fletcher
6. Kenton Richardson - 5
Generally solid but allowed Rob Hall too much space around the edge of the box for Oxford's equalising goal. | Other 3rd Party Photo: Mark Fletcher
7. Gus Mafuta - 6
Did his best to win the midfield battle but was booked for his troubles. A solid first half but a fairly quiet second as Pools let the game slip past them. | Other 3rd Party Photo: FRANK REID
8. Nicky Featherstone - 5
Looked a bit tired having played a lot of consecutive matches in recent weeks. The pace and tempo of Oxford’s midfield caused problems. | Other 3rd Party Photo: Mark Fletcher