Boro have failed to beat the Bees in their last five encounters, the most recent of which saw them knocked out of the FA Cup with a 2-1 defeat in west London.
As things stand, Neil Warnock’s side stand an excellent chance of making the play-offs, and picking up a big win against the Bees would be an excellent morale-booster as they look to continue their push towards a top-six finish.
Ahead of the weekend's clash, Warnock discussed star men Paddy McNair and Marcus Tavernier, and claimed: "For me, Paddy could play at any level now, he could play in the top half of the Premier League."
“I think he knows now to forget about midfield because he’s just an average player in midfield but at the back he’s unbelievable.
“Tav has got a lot to learn but he is learning all the time, he frustrates a manager and can pick an argument with his shadow at times but other than that he’s learning all the time and he will improve."
Here's our round-up of all the latest news and transfer chat involving Middlesbrough and a number of their divisional rivals, as we gear up for another action-packed weekend of second-tier football.
1. Balogun up for grabs this summer
Swansea City and Brentford-linked striker Folarin Balogun has been tipped to leave Arsenal this summer, after failing to break into their first-team. The 19-year-old has impressed during Europa League cameos this season. (Express) Photo: PAUL FAITH
2. Rooney pleased with experienced additions
Derby County boss Wayne Rooney has claimed the "experience" offered by his glut of new signings will prove to be an invaluable influence on his squad, after the Rams brought in no fewer than five loan players on deadline day. (Club website) Photo: Gareth Copley
3. Ex-Watford star opens up on new move
Udinese forward Gerard Deulofeu has revealed he's delighted to have completed a permanent move to the Serie A outfit from Watford, and has enjoyed playing alongisde his former Hornets teammate Roberto Pereyra. (Sport Witness) Photo: Alessandro Sabattini
4. King picks Toffees over contract length
Josh King's late transfer deadline day decision to join Everton over Fulham was believed to be largely down to contract length, with a potential return to the Championship on a longer deal with the Cottagers turning him off the move. (The Athletic) Photo: Naomi Baker