The Boro boss will still be without several first-team players, including Dael Fry, Anfernee Dijksteel, Sam Morsy and Marcus Tavernier, due to injury.
It means the Teessiders’ bench will once again be made up of mostly under-23s players, including teenage striker Josh Coburn, who recently scored his first senior goal against Sheffield Wednesday.
Warnock has been deploying a back three in recent weeks due to his lack of options, with Paddy McNair, Grant Hall and Marc Bola starting in defence.
Boro will start the day 10th in the Championship and have little to play for in terms of their divisional status for next season.
Wycombe, meanwhile, sit bottom of the division and, while they haven’t mathematically been relegated, their inferior goal difference has realistically ended their survival hopes.
Here’s how Boro could start.
1. GK: Jordan Archer
Saved a penalty at Luton last weekend and will be hoping to earn a new contract. Photo: Stu Forster
2. CB: Paddy McNair
Warnock prefers the Northern Ireland international at the back and McNair has impressed on the right of a back three. Photo: Alex Pantling
3. CB: Grant Hall
Produced another fine performance at Luton in the heart of Boro's defence. Photo: Stu Forster
4. CB: Marc Bola
Has moved into a left-sided centre-back role in recent weeks. The defender has enjoyed a fine season. Photo: Alex Burstow