Wycombe took the lead after just three minutes after an excellent strike from Uche Ikpeazu, before goals from Marcus Browne, Marcus Tavernier and Chuba Akpom gave the visitors all three points.
Our Boro writer Joe Nicholson has dished out his marks from the match– scroll down and flick through the pages of our picture gallery to see how each player fared:
1. Marcus Bettinelli - 7
Couldn’t do anything with the goal. Made an important save at the end of the first half after Boro took the lead. 7 Photo: Alex Pantling
2. Anfernee Dijksteel - 6
Most of Boro’s attacks came down the opposite flank in the first half. Stuck to his task defensively. 6 Photo: Clive Brunskill
3. Paddy McNair - 7
Recovered from a sticky start after allowing Ikpeazu to cut inside and score. Deliveries from set-pieces caused problems. 7 Photo: Alex Pantling
4. Dael Fry - 7
Won some important headers and interceptions when Boro were under pressure in the second half. 7 Photo: PA