Wycombe took the lead after just three minutes after an excellent strike from Uche Ikpeazu, before goals from Marcus Browne, Marcus Tavernier and Chuba Akpom gave the visitors all three points.
Our Boro writer Joe Nicholson has dished out his marks from the match– scroll down and flick through the pages of our picture gallery to see how each player fared:
5. Marc Bola - 6
Tried to get forward on the left and linked up well with Marvin Johnson at times. 6 Photo: Clive Brunskill
6. Sam Morsy - 7
Regularly came up against the imposing Ikpeazu in the first half as the Wycombe striker dropped deep. Kept battling and breaking up play in midfield. 7 Photo: Alex Pantling
7. George Saville - 6
A few loose passes early on but played his part defensively as Boro withstood Wycombe’s pressure at the start of the second half. 6 Photo: Getty Images
8. Marcus Tavernier - 8
A quiet start but turned the game around with an excellent strike to put Boro ahead. Tried to get on the ball and was unfortunate not to add a second goal. 8 Photo: George Wood