Wycombe took the lead after just three minutes after an excellent strike from Uche Ikpeazu, before goals from Marcus Browne, Marcus Tavernier and Chuba Akpom gave the visitors all three points.
Our Boro writer Joe Nicholson has dished out his marks from the match– scroll down and flick through the pages of our picture gallery to see how each player fared:
9. Marvin Johnson - 8
Was a regular outlet on the left and delivered some dangerous crosses into the Wycombe box. 8 Photo: George Wood
10. Marcus Browne - 7
Operated in the No 10 position and grew into the game. Levelled the score with a strong header. 7 Photo: Getty Images
11. Chuba Akpom - 7
Made some probing runs off the ball and got his reward when he scored from a corner ten minutes from time. 7 Photo: Getty Images
12. Djed Spence - 6
(for Browne, 71) Provided fresh legs in the closing stages. 6 Photo: Clive Brunskill