Neil Warnock’s side are still just two points above the relegation zone and will be hoping to bounce back following Saturday's 3-1 defeat by Bristol City. Our Boro writer Joe Nicholson has picked the side he would choose to face the Royals – scroll down and flick through our picture gallery to see if you agree:
1. GK: Dejan Stojanovic
Has been Boro's first-choice stopper since the restart. Photo: JPI Media
2. RWB: Djed Spence
Received some high praise from Warnock last week and is suited to the right wing-back role. Photo: Justin Setterfield
3. CB: Ryan Shotton
Was excellent at Millwall and caused problems with his long throw-ins against Bristol City. Photo: Getty Images
4. CB: Dael Fry
Had a difficult afternoon against Bristol City but had shown signs of improvement under Warnock. Boro's only natural centre-back now Harold Moukoudi has departed. Photo: Alex Davidson