The Teessiders will be without long-term absentees Dael Fry, Marcus Tavernier, Anfernee Dijksteel, Sam Morsy and Marcus Browne for the match.
Winger Nathaniel Mendez-Laing has been sidelined with a thigh issue, while Grant Hall and Darnell Fisher are also doubts for the match.
Boro only named five outfield substitutes during their 2-1 win over Rotherham last time out, none of whom had any previous experience in the Championship.
That did allow midfielder Connor Malley to come on and make his senior debut, though, and the 21-year-old may be handed his first senior start against Wednesday.
Warnock has also said he wants to give young goalkeeper Sol Brynn a game before the end of the campaign.
Here’s the Boro side we think could start this weekend.
5. LB: Hayden Coulson
Impressed off the bench against Cardiff and will be pushing for a recall at Hillsborough. Photo: Jan Kruger
6. CM: Adam Clayton
Missed the Cardiff game due to family reasons but should be available to face Wednesday. Boro will need him due to Jonny Howson's suspension. Photo: Alex Davidson
7. CM: George Saville
Has started every game under Warnock and has looked like a better player in a box-to-box midfield role. Photo: COPYRIGHT (C) FRANK REID 20187
8. CM: Paddy McNair
Has started on the bench for Boro's last two games, but Howson's suspension and Wednesday's threat in central midfield may mean the Northern Ireland international is recalled. Photo: FRANK REID 2020