The Teessiders will be without long-term absentees Dael Fry, Marcus Tavernier, Anfernee Dijksteel, Sam Morsy and Marcus Browne for the match.
Winger Nathaniel Mendez-Laing has been sidelined with a thigh issue, while Grant Hall and Darnell Fisher are also doubts for the match.
Boro only named five outfield substitutes during their 2-1 win over Rotherham last time out, none of whom had any previous experience in the Championship.
That did allow midfielder Connor Malley to come on and make his senior debut, though, and the 21-year-old may be handed his first senior start against Wednesday.
Warnock has also said he wants to give young goalkeeper Sol Brynn a game before the end of the campaign.
Here’s the Boro side we think could start this weekend.
9. RW: Patrick Roberts
Has operated in a central role recently but may be able to cause problems in a wider role against Sheffield Wednesday's wing-back system. Photo: COPYRIGHT (C) FRANK REID 20187
10. LW: Marcus Tavernier
Was Boro's best player against Cardiff after an impressive display at Reading. Can cause problems for opponents in the final third. Photo: Clive Brunskill
11. ST: Ashley Fletcher
Was on the fringes for most of the game against Cardiff but looked sharp in recent away games at Millwall and Reading. Photo: Clive Brunskill